Stopping Nogo

Yale University researchers have identified a receptor for an axonal growth inhibitor called Nogo. Although there are several groups working in the field of neural regeneration and remyelination, this target receptor will not lose value even if other therapeutics, such as nerve growth factors, progress to market first because of its specificity and the multilayered nature of CNS injury.

Nogo is a membrane protein found on central nervous system oligodendrocytes. It has an intracellular tail with no identified signaling function and an extracellular region that has been implicated in the failure of CNS axons to regenerate following injury to the brain or spinal cord...