Obesity and Type 2 diabetes are strongly associated, but the biochemical basis had not been identified. A protein called resistin that is secreted by fat cells may be that link. New work by University of Pennsylvania researchers shows that resistin decreases insulin sensitivity, a hallmark of diabetes.

Thiazolidinediones, a marketed class of anti-diabetic drugs, likely works through the resistin pathway, and more definitive data on the importance of resistin may increase the use of these second-line agents