Current treatments for diabetes rely on numerous daily blood glucose measurements and insulin injections and adherence to a strict diet, yet patients still live with risk of retinopathies, circulatory problems leading to limb loss, and hypoglycemic crises. Researchers at the University of Calgary and Yonsei University in Korea have reported long term resolution of clinical signs of Type I diabetes in animal models from a single treatment using an adeno-associated viral vector (AAV) construct containing