Monday, September 25, 2000
Kinases are important drug targets because they are involved
in an enormous number of cellular signaling pathways. However, the ubiquity
of kinases makes it difficult to get selective inhibitors that just hit one
kinase, even if the role of the kinase is known.
Kevan Shokat of the University of California at San Francisco
and colleagues last week published in Nature, a chemical genetic approach to
rapidly dissect out the roles of individual kinases - an approach that is much
more efficient than traditional methods.