Elucidating the cholesterol pathway

Despite appearing as co-authors on a paper on the role of retinoid X receptors in cholesterol balance, Ligand Pharmaceuticals Inc. and Tularik Inc. have no partnership in the area, and will apply the findings to their separate agendas.

As reported last week in Science, LGND's LG268 RXR ligand demonstrated a dose-dependent inhibition of cholesterol absorption from diet in mice and hamsters. LG268 repressed