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End points for angiogenesis
Monday, March 20, 2000
The potential benefits of angiogenesis therapy in treating
cardiovascular conditions are obvious in theory, but in practice they are proving
challenging to demonstrate. This doesn't mean the theory is wrong, but it may
mean that companies have to rethink the end points they pick for clinical trials.
Angiogenesis uses growth factors to stimulate blood vessel
formation to circumvent blocked vessels. Among presentations at the American
College of Cardiology meeting in Anaheim last week were a Phase II trial from
Chiron Corp. that failed to show significant efficacy, and a Phase I/II open-label
trial by Vascular Genetics Inc. that showed positive results.
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