Monday, November 2, 1998
Zebrafish may have made a splash among genetic investigators
impressed by their breeding speed and other capabilities, but their relevance
for human disease now has been made evident through their use as animal models.
Mutant fish can fully recapitulate two inherited blood disorders,
researchers reported in Nature Genetics. Moreover, the transparent embryos are
easily diagnosed - a look through the microscope easily reveals the size and
color of their defective red blood cells. The cells resemble those of mammals
but retain the cell nucleus.