Susceptibility catalog
The growing knowledge base of pharmacogenomics and the Human Genome Project should be helpful in a new project launched by The National Institute of Environmental Health Sciences. The NIEHS seeks to determine how 200 genes thought to affect an individual's interaction with the environment vary among 1000 people representative of the U.S. population.
NIEHS is seeking suggestions from the scientific community for candidate genes that determine susceptibility to or protection from toxins and carcinogens, as well as responses to diet. Such genes are expected to fall into categories like metabolism, immune responses, cell cycle, oxidative stress, signal transduction, apoptosis, nutrition, DNA repair and detoxification (see Online Links, A13). ...