Monday, September 8, 1997
Two papers in last week's Cell demonstrate that HIV's mode of entry into T cells can be turned against it.
HIV enters T cells by binding to the coreceptors CD4 and CXCR4. After internalization and replication, infected T cells express HIV membrane glycoproteins on their surface in preparation for the release of more HIV into the blood. These glycoproteins, gp120 and gp41, are the very same proteins that allowed viral entry in the first place.