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Takeda's Millennium subsidiary is using an in vivo screening platform from Presage to speed up preclinical characterization of cancer combination therapies.
Published on 5/7/2012
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AstraZeneca has concluded that Conformetrix has perfected an NMR-based technology to quickly and accurately determine bioactive conformations of compounds in solution.
Published on 4/30/2012
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Through early access programs with pharma customers, Cellular Dynamics is gathering data that show its iPS cells predict hepatic and cardiac toxicity better than conventional assays.
Published on 3/26/2012
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With a new CSO and an injection of venture money, Sutro is ready to pick lead indications where it can use its cell-free biochemical protein synthesis technology to quickly enter the clinic with biosuperiors.
Published on 1/10/2011
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LineaGen hopes to parlay its efforts to identify rare autism-linked genetic variants into a testing business built around a microarray-based diagnostic platform.
Published on 11/1/2010
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Advanced Cell Diagnostics has launched a single molecule RNA detection technology it believes will provide a more sensitive level of detection than protein-based assays.
Published on 8/23/2010
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Cellular Dynamics International Inc. has overcome a technical hurdle that has until now prevented the use of stem cell technologies to …
Published on 1/4/2010
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Replidyne Inc. last week unveiled REP3123, a MetRS inhibitor in preclinical development that the company thinks will be more effective …
Published on 9/24/2007
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Technology Small PEGs Over the past decade, Nektar Therapeutics' pegylation capabilities have provided a growing royalty stream via third party sales of biologics that use the technology. Now, internal products that…
Published on 9/24/2007
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Technology Targeting mucosal inflammation Biogen Idec Inc. has long been interested in the late stages of inflammation where tissue remodeling and fibrosis occur. Last week's deal with LigoCyte Pharmaceuticals Inc. …
Published on 9/24/2007
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Technology Complementing MAbs Biothera thinks its Imprime PGG beta-glucan, a soluble carbohydrate, could be combined with complement-fixing MAbs to improve their efficacy compared to the MAbs alone in some cancers.…
Published on 9/17/2007
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Technology Ready, steady, glow Researchers at Stanford University School of Medicine have developed an advanced activity-based probe they say will allow drug companies to make faster, earlier and perhaps even …
Published on 9/17/2007
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The pharmaceutical industry rarely uses free energy perturbation-based methods in computer-aided drug design because these methods have low …
Published on 9/10/2007
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Sodium channels are large voltage-gated transmembrane proteins that play an important role in many physiological processes by …
Published on 8/27/2007
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In the last few years, companies have started pursuing agonism of SIRT1 as a way of boosting the body's metabolism to treat Type II diabetes, while …
Published on 8/27/2007
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Technology Dynamic dimerization InNexus Biotechnology Inc. chose a well-validated target, CD20, to show that its second generation, conjugated monoclonal antibodies are more potent than first generation, …
Published on 8/13/2007
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Technology Dysfunction stymies HDL Although raising HDL is a major focus for many companies generating small molecule atherosclerosis therapies, the strategy has not yet led to clinical benefit. Researchers from the…
Published on 8/13/2007
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Researchers from the University of North Carolina at Chapel Hill reported in the Journal of Experimental Medicine the identification and …
Published on 8/13/2007
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Technology: Apoptosis shortcut Caspase cascade By targeting procaspase-3, BioLineRx Ltd. believes BL-4030 can bypass upstream elements in the intrinsic and extrinsic apoptosis pathways. In the intrinsic pathway, the…
Published on 7/30/2007
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Caspase cascade Targeting proteins in the apoptotic pathway can be difficult because the pathway is often rendered nonfunctional by mutations and …
Published on 7/30/2007
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Isis Pharmaceuticals Inc. believes it is the first to show preclinical efficacy with a novel obesity target - mitochondrial dicarboxylate carrier (mDIC…
Published on 7/9/2007
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Lexicon Pharmaceuticals Inc. published data last week showing that its antibodies against angiopoietin-like protein 4 produce …
Published on 7/9/2007
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Ever since Nuvelo Inc. was formed through the merger of Hyseq Pharmaceuticals Inc. and Variagenics Inc. in 2003, the company's clinical focus has …
Published on 6/18/2007
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While a presidential veto looms for the embryonic stem cell legislation that passed the U.S. House of Representatives last week, three …
Published on 6/11/2007
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Mass spectrometry-based proteomics can reveal protein-protein interactions using large sample sizes and analyzing binding relationships long after a cell …
Published on 6/4/2007