We have entered an age of austerity that, given the fecklessness of the political classes, won't end any time soon. Against that backdrop, the global science community must decide how to succeed with less money.

Major changes in the way science is funded and conducted are needed to ensure the most pressing scientific problems are addressed by the best scientists. The patients who rely on the biomedical innovation ecosystem deserve nothing less, and the taxpayers who foot the bill should be demanding it.