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Merck adds Endocyte's vintafolide to its personalized cancer portfolio
Merck's platinum play
By Michael Flanagan
Senior Writer
Published on
Monday, April 23, 2012
Merck
& Co. Inc. has sifted through seemingly conflicting data and
concluded the PFS benefit in a Phase II trial in platinum-resistant ovarian
cancer was robust enough to justify paying $120 million up front for Endocyte
Inc.'s vintafolide. The deal fits Merck's interest in personalized
cancer medicines and could give Endocyte a head start on building a commercial
organization.
Vintafolide (EC145) is a
conjugate consisting of a vinca alkaloid microtubule destabilizer connected via
a linker to a folate vitamin analog. The molecule is being tested in the Phase
III PROCEED trial.
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