BioCentury on BioBusiness,
Product Discovery & Development
Convergence data show safety, efficacy of Nav1.7 blocker in neuralgia pain
Monday, June 23, 2014
Pharmaceuticals Ltd. last week for CNV1014802 to treat trigeminal neuralgia
gave the first Phase
II evidence that
systemic Nav1.7 blockers can treat pain safely and effectively. The data also
lend further support to the theory that part-time blockage of the channel is
enough to be effective.
(SCN9A) channel is found on pain-responsive neurons. It was identified as a
target for pain disorders in 2006 with the discovery of loss-of-function
mutations in members of several families with congenital insensitivity to pain.
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