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Table: Measuring up in RA
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Monday, December 16, 2013
Phase III data suggest sarilumab from Regeneron
Pharmaceuticals Inc. (NASDAQ:REGN) and partner Sanofi (Euronext:SAN;
NYSE:SNY) may have similar efficacy in moderate to severe rheumatoid arthritis
as Actemra tocilizumab. Both are anti-interleukin-6 (IL-6) receptor (CD126)
antibodies. The Genentech Inc. unit of Roche (SIX:ROG;
OTCQX:RHHBY) markets Actemra in IV and subcutaneous versions. Regeneron thinks
sarilumab, which is given SC every other week, will be competitive based on its
dosing regimen. SC Actemra was given both every week and once every other week
in the Phase III program, but the recommended dosage is once every other week,
followed by an increase to every week based on clinical response, in patients
weighing <100 kg. Three other IL-6 blocking therapies - ALX-0061,
clazakizumab and sirukumab - have shown efficacy in Phase II. Sirukumab is
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