BioCentury on BioBusiness,
Product Discovery & Development
How next-gen ADCs aim to improve homogeneity, go beyond cancer
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The next wave in ADCs
Monday, August 19, 2013
After about 25 years of development, antibody-drug conjugates
have gained acceptance as a validated approach to the targeted killing of
cells, with two drugs approved in the past two years. While Seattle
Genetics Inc. and ImmunoGen
Inc. have owned the space, a variety of biotechs are developing
next-generation ADCs that seek to improve the technology and broaden its scope
beyond cancer to inflammation and autoimmune diseases.
These advances include
producing a more homogeneous drug product and delivering more potent payloads
that move beyond the delivery of blunt, cytotoxic agents. Other approaches
include developing ADCs as a delivery system for targeted small molecules.
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