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Table: Checking up on melanoma
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Monday, June 10, 2013
Phase I proof-of-concept data presented at last week's
American Society of Clinical Oncology
meeting in Chicago suggest the next wave of immunotherapies in melanoma could
generate better tumor responses than Yervoy ipilimumab with the same or better
safety profile. Yervoy is a first-generation mAb immune checkpoint inhibitor
that targets CTLA-4 (CD152). It was approved in 2011 and is marketed by Bristol-Myers
Squibb Co. (NYSE:BMY) to treat unresectable or metastatic melanoma. At ASCO,
new checkpoint inhibitor mAbs from BMS,
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