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Neomics targets new functions of aminoacyl tRNA synthetases for cancer
Neomics' new tricks
Monday, March 11, 2013
Co. Ltd. is leveraging previously unknown functions of aminoacyl tRNA
synthetases and their interacting proteins to build a pipeline of therapeutics
and diagnostics for cancer. The most advanced program focuses on detecting and
targeting an oncogenic splice variant of AIMP2 that may be overexpressed in
lung, colon and ovarian cancers.
Aminoacyl tRNA synthetases
(ARSs) have been known for almost four decades as essential housekeeping
enzymes that attach the correct amino acid to tRNA during protein synthesis.
Since all cells require this process, human ARSs were generally not considered
useful therapeutic targets.
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