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Product Discovery & Development
Forward Pharma aims for better version of dimethyl fumarate for psoriasis
Divergent DMF paths
Monday, January 7, 2013
Pharma A/S has taken a different path to improve the safety and
efficacy of fumarate than has Biogen
Idec Inc. While Biogen's BG-12 is under review for multiple sclerosis,
Forward has set its sights on psoriasis with a controlled-release formulation
that could have better tolerability than either first-generation fumarates or
Fumarate has been used to treat
psoriasis in Europe since the 1950s. Fumaderm, a first-generation oral dimethyl
fumarate (DMF) marketed in Germany by Biogen Idec, is the most prescribed psoriasis
drug in that country because it does not carry serious side effects, such as
immunosupression, that are found with first-line oral methotrexate and
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