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Product Discovery & Development
Nimbus solves IRAK4 puzzle for mutation-defined subtypes of B cell lymphomas
Nimbus' lymphoma watershed
Monday, December 24, 2012
It has taken Nimbus
Discovery LLC just three years from its founding to identify lead
inhibitors against the historically intractable target IRAK4 to treat
autoimmune disease and cancer. This month the company presented preclinical
data showing that combining IRAK4 and Btk inhibitors had a synergistic effect
in mutation-defined subtypes of two B cell lymphomas.
IL-1 receptor-associated kinase 4 (IRAK4) plays a role in
innate immune signaling and has been implicated in autoimmune diseases such as
rheumatoid arthritis (RA), psoriasis and gout. In 2011, a team at the National
Cancer Institute showed for the first time that IRAK4 inhibitors had
potential in B cell lymphomas (see SciBX: Science-Business eXchange, Jan.
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