BioCentury on BioBusiness,
Product Discovery & Development
Nimbus solves IRAK4 puzzle for mutation-defined subtypes of B cell lymphomas
Nimbus' lymphoma watershed
Monday, December 24, 2012
It has taken Nimbus
Discovery LLC just three years from its founding to identify lead
inhibitors against the historically intractable target IRAK4 to treat
autoimmune disease and cancer. This month the company presented preclinical
data showing that combining IRAK4 and Btk inhibitors had a synergistic effect
in mutation-defined subtypes of two B cell lymphomas.
IL-1 receptor-associated kinase 4 (IRAK4) plays a role in
innate immune signaling and has been implicated in autoimmune diseases such as
rheumatoid arthritis (RA), psoriasis and gout. In 2011, a team at the National
Cancer Institute showed for the first time that IRAK4 inhibitors had
potential in B cell lymphomas (see SciBX: Science-Business eXchange, Jan.
words displayed of
To read this article, you must be an Archives subscriber. Please choose one of the options below.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Whether you want an individual subscription or need a global group license, we have the products,
the experience and the customer support that biopharma executives, researchers, investors, service providers,
and industry stakeholders have trusted for nearly two decades.
Let our Subscriber Services team customize the best intelligence package available in the industry to meet your needs.
Free Trial Subscription 4 Weeks of Access
BioCentury's Weekly Business Intelligence Journal
Get a 4-week free trial subscription to BioCentury.
Get 4 Weeks Free
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]