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Product Discovery & Development
Cholesterol data from Amgen sheds light on race between anti-PCSK9 mAbs
Related tables, figures and sidebars
Piecing together PCSK9
Monday, November 12, 2012
Last week's Phase II data for anti-PCSK9 mAbs from Amgen
Inc. and Pfizer
Inc. revealed no surprises and kept intact the hypothesis that hitting
the target is a new modality for lowering cholesterol with or without statin
background therapy. The data do allow for a rough comparison between Amgen's
molecule and the most advanced member of the class - twice monthly REGN727 from
Pharmaceuticals Inc. and Sanofi
- and show no clear winner.
While Pfizer is keeping mum on
how it hopes to differentiate its RN316 (PF-04950615) from the pack, Amgen
thinks it could come down to dosing. Indeed, the biotech bellwether hopes to
counter REGN727's six to nine month head start in the clinic by offering a
monthly dosing option for AMG 145.
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