BioCentury on BioBusiness,
Product Discovery & Development
Ardelyx lands first partner as AstraZeneca moves into diabetic complications
Gut instinct
By Chris Cain
Senior Writer
Published on
Monday, October 15, 2012
Ardelyx
Inc. took its gut-specific small molecule approach from concept to
Phase II testing in under four years and now has scored a partnership with AstraZeneca
plc as the pharma adds diabetic complications as a new therapeutic
area.
The deal grants AstraZeneca
exclusive worldwide rights to RDX5791, a non-absorbed inhibitor of
solute carrier family 9 sodium hydrogen exchanger member 3 (SLC9A3; NHE3) in development
for end-stage renal disease (ESRD), chronic kidney disease (CKD), heart failure
and constipation-predominant irritable bowel syndrome (IBS-C).
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