BioCentury on BioBusiness,
Product Discovery & Development
How in vitro tox presaged Bristol-Myers' costly failure with Inhibitex HCV drug
Monday, September 10, 2012
Squibb Co. may have looked past in vitro safety signals in a
rush to add Inhibitex Inc.'s nucleoside NS5B polymerase inhibitor to its HCV portfolio.
If the pharma was gambling that it could find a therapeutic window for
BMS-986094 as it had previously done with blockbuster entecavir in HBV, the bet
In August, BMS first suspended
and then terminated development of BMS-986094 after nine patients in a Phase II
trial were hospitalized with heart and kidney toxicities, including one patient
who died of heart failure.
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