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Product Discovery & Development
ArQule believes interstitial lung disease in tivantinib trial specific to Japan
Japan Factor Resurfaces
Monday, September 10, 2012
Although an increased rate of interstitial lung disease caused
Hakko Kirin Co. Ltd. to suspend a Phase III trial of tivantinib for
non-small cell lung cancer, ArQule
Inc. believes the phenomenon is specific to the Japanese population and
thus won't affect development of the compound elsewhere.
Kyowa, which has rights to
tivantinib in Japan and other Asian countries, suspended enrollment in the
Japanese Phase III ATTENTION trial late last month after seeing an imbalance in
interstitial lung disease in the treatment arms.
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