BioCentury on BioBusiness,
Product Discovery & Development
Zytiga plus Provenge could become SOC in chemo-naïve metastatic prostate cancer
Zytiga zooms to front
Monday, June 11, 2012
Based on positive Phase III results for Johnson
& Johnson's Zytiga abiraterone in chemotherapy-naïve, metastatic
castration-resistant prostate cancer, most doctors contacted by BioCentury
expect to start using the drug in earlier-stage disease, even before regulators
FDA approved Zytiga in 2011 to treat metastatic CRPC
patients who have received prior docetaxel-containing chemotherapy. Approval
was based on a single Phase III trial in which Zytiga plus prednisone improved
OS by 3.9 months vs. placebo plus prednisone (14.8 months vs. 10.9 months;
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