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Vismodegib, saridegib shed light on hedgehog inhibition in specific cancers
Mechanism matters
By Andrew Fisher
Staff Writer
Published on
Monday, March 5, 2012
The different mechanisms by which the hedgehog pathway drives
specific cancers could explain why Genentech
Inc.'s Erivedge vismodegib received FDA approval for advanced basal
cell carcinoma while Infinity
Pharmaceuticals Inc.'s saridegib failed in pancreatic cancer.
In January, Infinity reported
data from 122 patients in the double-blind Phase II portion of a Phase Ib/II
trial in metastatic pancreatic cancer. Saridegib plus gemcitabine produced
median overall survival of <6 months, worse than in the arm receiving
gemcitabine plus placebo.
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