BioCentury on BioBusiness,
Product Discovery & Development
How Threshold's switch has paid off with Merck deal and pancreatic data
Pancreatic payoff
By Aaron Bouchie
Senior Writer
Published on
Monday, February 27, 2012
Threshold
Pharmaceuticals Inc. has long been focused on diseases that are
characterized by hypoxic tissue, such as cancer and benign prostatic hyperplasia,
but its first efforts based on hypoxic cell reliance on glucose metabolism didn't
work out. The company's decision in 2007 to work instead on hypoxia-activated
prodrugs has now paid off.
Last week, Threshold's TH-302 met the primary endpoint of PFS
in a Phase IIb trial to treat pancreatic cancer, triggering a $20 million
milestone on top of $25 million it received up front under a two-week-old deal
with Merck
KGaA to co-develop and commercialize the compound.
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