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Product Discovery & Development
Thrasos built BMP activators to treat kidney injury, avoid unwanted bone growth
Bone-free BMP
By Aaron Bouchie
Senior Writer
Published on
Monday, October 10, 2011
Thrasos
Innovation Inc. believes its selective bone morphogenetic protein
receptor activators will work for kidney disease because they trigger the BMP
pathway's anti-inflammatory, anti-apoptotic and antifibrotic properties, but
not its osteogenic properties.
BMP has been in development for kidney disease at least since
the mid-'90s. In 1996, Creative BioMolecules Inc., now Curis
Inc., presented data showing that bone morphogenetic protein 7 (BMP7;
OP-1) protected against kidney damage in animal models of chronic and acute
renal failure.
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