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Product Discovery & Development
Cancer researchers predict altered dosing of Tarceva could avoid resistance
Simple fix for EGFR resistance
Monday, August 1, 2011
All non-small cell lung cancer
patients on the EGFR inhibitors Tarceva erlotinib and Iressa gefitinib
eventually develop resistance to the drugs and progress. A predictive model
developed by a team of cancer researchers suggests simply altering the dosing
regimens of the drugs may be sufficient to prevent or delay resistance.
Two small molecule EGFR inhibitors are marketed to treat
its Genentech Inc. unit and Astellas
Pharma Inc. market Tarceva in the U.S. and EU. AstraZeneca
plc markets Iressa in the EU. The standard regimen is the maximum
tolerated once daily dose of drug until progression occurs.
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