BioCentury on BioBusiness,
Product Discovery & Development
Extended effectiveness of PDLI's antibodies
Monday, April 4, 1994
Protein Design Labs Inc. (PDLI) has presented animal data showing that four of its
human or humanized antibodies persist for several weeks, giving clues as to which products
may be effective with infrequent dosing.
Murine monoclonals generally require once-a-day dosing, the company noted, whereas
PDLI's results in Rhesus monkeys suggest that once every two weeks might suffice for
certain human or humanized versions. Paul Nadler, vice president for medical and
regulatory affairs, told BioCentury it now may
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