Regulatory milestones

Ariad Pharmaceuticals Inc. (NASDAQ:ARIA) was off $0.23 to $18.69 last week after beginning submission of a rolling NDA to FDA for ponatinib to treat resistant or intolerant chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The company, which requested Priority Review, is seeking accelerated approval based largely on data from the pivotal Phase II PACE trial.