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Zebra Biologics uses Scripps technology for functional antibody selection
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Zebra Biologics: Antibody express
Monday, March 3, 2014
Biologics Inc. is using technology licensed from The
Scripps Research Institute that accelerates the functional
characterization of antibodies by pooling Abs that bind to a given target into
a single cell-based reporter system. The biotech has used the technology to
generate antibodies that agonize the previously intractable metabolic disease
targets adiponectin receptor 1 and ADIPOR2.
Antibody generation typically
relies on two core methods: an in vivo approach in which an antigen is
injected into a mouse; or an in vitro approach such as phage display.
Both approaches generate a large number of antibodies and are followed by
multiple binding experiments to identify those with affinity to targets of
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