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ARTICLE | Emerging Company Profile

Tube: Potent payloads

Tube's tubulysin conjugate payload may allow targeting of resistant cancers

September 23, 2013 7:00 AM UTC

The potency of Tube Pharmaceuticals GmbH's tubulysin toxin as a conjugate payload could allow the company to target resistant cancers. Tube is developing a polymer-tubulysin conjugate for solid tumors and has out-licensed the toxin for use in other conjugate therapeutics.

Like auristatins and maytansine, which are used as payloads in antibody-drug conjugates (ADCs), tubulysin is a microtubule-disrupting agent...