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Tansna developing non-sedating propofol analogs for refractory epilepsy
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Tansna: Quieting convulsions
Monday, September 16, 2013
Propofol is used off-label in hospitals to treat uncontrolled
seizures, but its potent sedative properties preclude everyday use. Tansna
Therapeutics Inc. is developing non-sedating analogs of propofol
that could help treat the one-third of epilepsy patients who are refractory to
marketed maintenance therapies.
Scientific founder Max Baker, associate professor in the
Department of Anesthesia at the University
of Iowa, was actually looking for a sedative with faster recovery. But
his MB003, a para-substituted analog of propofol, turned out to be a poor
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