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ARTICLE | Emerging Company Profile

Jounce: Regulating the regulators

Jounce looking for new immune targets for antibody cancer immunotherapies

July 29, 2013 7:00 AM UTC

Jounce Therapeutics Inc. is intent on discovering new immune regulatory targets that it hopes will result in a large portfolio of antibody-based immunotherapies to treat many solid cancers.

Cancer immunotherapies typically induce T cells to attack and destroy a patient's tumor cells and thus extend survival. In principle, this could be accomplished by agonizing positive regulators of T cell activity or by inhibiting immune checkpoint proteins, which are negative regulators of T cell activity...