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Oxford Cancer Biomarker finding functionally relevant drug-specific biomarkers
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Oxford Cancer: Functional silence is golden
Monday, July 15, 2013
Cancer Biomarkers Ltd.'s CancerNav cell-based screening platform may be
able to more accurately identify genes that influence drug sensitivity than
traditional in vitro methods that do not provide insight into a
biomarker's functional relevance. The company is using CancerNav to discover
biomarkers for predicting patient response to new cancer therapies.
CancerNav is a loss-of-function
screen that uses a library of small hairpin RNA (shRNA) molecules to
generate a panel of cancer cells, each of which has a different gene silenced.
By treating the entire panel with the same cytotoxic compound and noting which
cells continue to grow, researchers can identify the gene or genes that are
necessary for the compound's cytotoxicity or antiproliferative effects. Those
genes then become biomarkers of sensitivity to that particular compound.
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