BioCentury on BioBusiness,
Emerging Company Profile
Oxford Cancer Biomarker finding functionally relevant drug-specific biomarkers
Related tables, figures and sidebars
Oxford Cancer: Functional silence is golden
Monday, July 15, 2013
Cancer Biomarkers Ltd.'s CancerNav cell-based screening platform may be
able to more accurately identify genes that influence drug sensitivity than
traditional in vitro methods that do not provide insight into a
biomarker's functional relevance. The company is using CancerNav to discover
biomarkers for predicting patient response to new cancer therapies.
CancerNav is a loss-of-function
screen that uses a library of small hairpin RNA (shRNA) molecules to
generate a panel of cancer cells, each of which has a different gene silenced.
By treating the entire panel with the same cytotoxic compound and noting which
cells continue to grow, researchers can identify the gene or genes that are
necessary for the compound's cytotoxicity or antiproliferative effects. Those
genes then become biomarkers of sensitivity to that particular compound.
words displayed of
To read this article, you must be an Archives subscriber. Please choose one of the options below.
All contents Copyright © 1993-2014 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Whether you want an individual subscription or need a global group license, we have the products,
the experience and the customer support that biopharma executives, researchers, investors, service providers,
and industry stakeholders have trusted for nearly two decades.
Let our Subscriber Services team customize the best intelligence package available in the industry to meet your needs.
Free Trial 4 Weeks of Access
Get a 4-week free trial subscription to see the important articles you are missing.
Get 4 Weeks Free
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]