Monday, June 24, 2013
Therapeutics aims to improve the therapeutic profile of drugs by
entrapping them within biodegradable polymeric nanoparticles. While the company's
CriPec platform has several characteristics in common with other polymer-based
nanoparticle carriers, it may be better able to increase efficacy and safety.
The platform uses
thermosensitive polymers that self-assemble into micelles when the temperature
is raised above a critical level. During the process, sections of the polymers
that make up the micelle core polymerize and form crosslinks with one another,
thus stabilizing the micelle to form the CriPec nanoparticle and preventing its
premature dissociation upon administration.