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Ultimovacs targeting multiple epitopes on the cancer target telomerase
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Ultimovacs: hTERT redux
Monday, May 13, 2013
AS is developing a telomerase-based cancer vaccine that could treat a
broader range of cancer patients than the most advanced telomerase vaccine in
the clinic by delivering multiple telomerase epitopes rather than a single one.
Human telomerase reverse
transcriptase (hTERT) is an attractive cancer target because it is absent from
most normal cells but is expressed and active in as many as 90% of tumors, where
it helps stabilize the cancer cell genome and drive long-term cell growth.
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