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Avilex's dimeric inhibitor shows greater potency for pain target PSD95
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Avilex: One-two pain punch
Monday, April 29, 2013
Pharma ApS may have found a way to block activation of the NMDA
receptor pathway to treat chronic pain and ischemic stroke. Rather than
directly hitting the receptor itself, the approach targets a downstream player
in the pathway and thus could avoid many of the side effects of NMDA receptor
The NMDA receptor is expressed
on the surface of many CNS cell types and is known to mediate production of
excess nitric oxide (NO), which leads to neuronal excitotoxicity and the
development of neuropathic and chronic pain as well as nerve damage following
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