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Vedantra developing nanoparticle-based vaccines for malaria, HPV
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Vedantra: Boosting T cell responses
By Tim Fulmer
Senior Writer
Published on
Monday, March 4, 2013
Vedantra
Pharmaceuticals Inc. is developing nanoparticle vaccines that are
designed to generate a more potent antibody and T cell response than traditional
subunit vaccines. By delivering antigens and immunostimulatory adjuvants in
multilayer lipid vesicles, the technology mimics the pathogen-associated
molecular patterns necessary for a robust immune response.
Subunit vaccines are typically
a mixture of one or more antigens from a target pathogen plus an adjuvant. They
are effective at triggering an antibody response but often elicit poor or even
no T cell responses. That is a problem because many viral diseases are thought
to require a highly potent T cell response in addition to an antibody response
to control and eradicate infection.
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