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Signum Dermalogix targets both mechanisms underlying rosacea
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Signum: Rosacea double play
Monday, February 18, 2013
Therapies on the market or in development for rosacea treat
either the symptomatic flushing or the inflammatory skin lesions. Signum
Dermalogix Inc.'s lead small molecule isoprenylcysteine analog could
treat both aspects of rosacea by targeting key inflammatory pathways.
The isoprenylcysteine (IPC)
motif occurs in multiple G proteins that interact with the intracellular
domains of G protein-coupled receptors (GPCRs). These interactions regulate
multiple processes, including the secretion of pro-inflammatory cytokines.
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