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Lipigon taking new approach to lipoprotein lipase to prevent atherosclerosis
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Lipigon: LPL protectorate
By Stephen Hansen
Senior Writer
Published on
Monday, December 3, 2012
Lipoprotein lipase has long been a desirable target to treat
atherosclerosis, but direct-acting activators of the enzyme have failed. Lipigon
Pharmaceuticals AB is taking a different tack, developing small
molecules that protect the enzyme from inactivation by endogenous inhibitors.
Lipoprotein lipase (LPL) plays
a central role in blood lipid metabolism. It hydrolyzes triglycerides -
resulting in formation of pre-beta HDL - and delivers free fatty acids to
peripheral tissues for use as energy or storage. The enzyme also facilitates
receptor-mediated uptake of atherogenic lipoproteins.
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