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Norway's Targovax developing vaccine targeting mutant Ras for pancreatic cancer
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Targovax: Ras to the rescue
Monday, November 12, 2012
A/S's peptide-based vaccine improved survival in an investigator-led
Phase I/II trial in resected pancreatic cancer, and the company is planning its
own Phase I/II trial this year. The vaccine works by going after mutant Ras, a
protein found in several types of cancer but generally considered a marker of
non-response to treatment instead of a therapeutic target.
Mutations in the Ras family of
genes - K-Ras (KRAS), v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS)
and neuroblastoma Ras viral (v-Ras) oncogene (NRAS) - are markers of resistance
to standard therapies in colorectal cancer (CRC) and non-small-cell lung cancer
(NSCLC) and are also found in up to 90% of pancreatic cancers.
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