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Fedora aims single bullet against beta lactamases for antibiotic resistance
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Fedora: Silver bullet against bugs
Monday, October 8, 2012
Pharmaceuticals Inc. aims to head
off bacterial growth with beta lactamase inhibitors that are effective against
all classes of the antibiotic resistance-conferring enzyme. The Canadian
startup hopes to advance one of its lead compounds into preclinical development
by year end.
Beta lactamases are a diverse
group of bacterial enzymes that degrade a variety of widely used antibiotics.
The enzymes fall into four major classes - A, B, C and D - that vary
considerably in their structure and biochemical characteristics, making it
difficult to find a universally effective inhibitor.
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