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Mind-NRG's neuregulin 1 fragment could treat early stage Parkinson's disease
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Mind-NRG: New neuroprotection
Monday, August 20, 2012
Approved therapies for
Parkinson's disease treat motor symptoms but cannot stop the loss of
dopaminergic neurons that causes them. Mind-NRG's neuregulin 1 fragment
could slow disease progression by preventing damage to dopaminergic neurons
before motor symptoms appear.
Neuregulin 1 (NRG1) plays a
critical role in neuronal development in the brain by agonizing epidermal
growth factor receptor 4 (EGFR4; HER4; ErbB4), which is highly expressed on
dopaminergic neurons. NRG1-ErbB4 signaling also regulates interactions between
glutamate and its receptors that are involved in cognition and memory.
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