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ARTICLE | Emerging Company Profile

Oncotide: SETting up phosphatases

Oncotide SET antagonists enhance phosphatase activity, disrupt cancer signaling

July 23, 2012 7:00 AM UTC

Oncotide Pharmaceuticals Inc. believes it has found a way to deactivate the phosphorylation that is a driver of oncogenic signaling, an approach that could provide an alternative or add-on to kinase inhibitors for blocking growth of tumor cells.

Rather than inhibiting kinases to restore normal phosphorylation and reduce the signaling of up-regulated oncogenic pathways, Oncotide is developing SET inhibitors to promote dephosphorylation of the oncogenic signaling molecules...