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SironRX using stromal cell-derived factor-1 gene therapy for wounds, scars
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SironRX: Sealing scars
Monday, July 9, 2012
Inc. spun out from Juventas
Therapeutics Inc. in 2010 to develop JVS-100 for wound healing and scar
prevention. The non-viral DNA plasmid encoding stromal cell-derived factor-1 is
designed to tackle both indications simultaneously, while competing products
are only able to address each indication distinctly.
Stromal cell-derived factor-1
is a naturally occurring chemokine that is rapidly over-expressed in response
to tissue injury, particularly during ischemia. It is responsible for a
variety of healing processes including the down-regulation of pro-inflammatory
mediators, recruitment of endothelial progenitor and stem cells, promotion of cell
preservation and stimulation of angiogenesis.
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