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Armour targets relaxin in prostate cancer; may complement anti-androgen drugs
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Armour: Relaxin in CRPC
Monday, June 18, 2012
Therapeutics Inc.'s relaxin receptor antagonists may provide a
complementary hormonal therapy that can be given either with or after
anti-androgen therapy in prostate cancer patients. Targeting a secondary
pathway alongside an androgen pathway could delay the time to when the disease
becomes hormone refractory.
Prostate cancer therapies have predominantly targeted the
androgen pathway, as aberrant androgen production drives tumor growth and
metastases. These treatments include older therapies such as androgen hormone
antagonists and newer compounds such as Zytiga abiraterone from Johnson
& Johnson, which suppresses androgen synthesis, and Medivation
Inc.'s enzalutamide, a next-generation androgen receptor antagonist.
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