BioCentury on BioBusiness, Emerging Company Profile
Arthur Krieg, Jeannie Lee, Atlas Ventures found epigenetics company RaNA
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RaNA: Specific in epigenetics
By Jon Wolleben
Staff Writer
Published on Monday, January 23, 2012
Most epigenetics companies aim to globally inhibit regulatory
proteins, such as histone methyltransferases or histone demethylases, which may
affect thousands of genes. RaNA
Therapeutics Inc. is instead targeting long non-coding RNA, or lncRNA,
to up-regulate gene expression in a locus-specific fashion. This could give it
a specificity advantage over other epigenetic approaches.
RaNA was founded in 2011 after Atlas Venture's Jean-Francois
Formela saw the potential to form a company based on Jeannie Lee's work at Massachusetts
General Hospital.
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