BioImage: Molecular traffic watch

One reason that good targets do not always lead to good therapeutics is the difficulty in developing specific small molecules that avoid binding interactions with homologs of the target that have little therapeutic relevance. BioImage is seeking to end run around the problem by tracking the movement of intracellular targets and developing small molecules that modify a target's location without directly interacting with the target.

The goal is to follow changes in the interactions of a protein within a signaling complex and track its intracellular translocation in real time in living cells. By doing so, BioImage hopes to identify small molecules that selectively modulate these protein interactions...