Monday, August 25, 1997
Emerging Company Profile
Working from the general to the specific is one way to learn how to discover new drugs. That's the strategy being pursued by Molecumetics Ltd., which conducts drug discovery by starting with the similarities among protein superfamilies and works down to the specific differences between individual drug targets.
Molecumetics concentrates its drug design efforts initially on choosing a scaffold that interacts with a particular protein superfamily - proteases, for example - on the theory that similarities in the targets' structures translate into similarities in their molecular mechanism of inhibition. Using this method to identify a candidate scaffold, the company then modifies the side chains and other structural details of the scaffold until it arrives at an active lead selective for a particular drug target.